Skip to main content
"(...) these experiments validate our predictions that endothelial cells in PAH patients are primed to respond in a significantly different way to growth factor stimuli than in healthy controls in a mechanism that likely involves enhancer-priming. Taken together, our data provide the epigenetic basis for aberrant AP1, TGFβ, serotonin and VEGF signaling that conspire to cause inflammation, aberrant angiogenesis and EndMT, and the propensity for smooth muscle cell proliferation, all features of PAH. Moreover, our results suggest that potential therapies should be considered not only by their impact on cell surface receptor or signaling pathways, but on whether they reverse the sequelae of the aberrant epigenetic landscape."

Read more here.